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A promising research breakthrough for the treatment of schizophrenia



A promising research breakthrough for the treatment of schizophrenia

In recent years, there has been no significant progress in scientific research on schizophrenia, a disease that recently returned to the news following the murder of a nurse by a psychotic in France. .

Scottish psychiatrist Robin Murray, who has devoted decades of his life to researching the disease, says that “drug treatments haven’t changed radically” in the field for twenty or thirty years.

In France, the serious psychological disorder was highlighted after a man with schizophrenia attacked a nurse with a knife in the French city of Reims a few days ago. It is feared that such incidents may create a negative stigma for all patients.

“All the years of work to destigmatize this disease collapsed in 24 hours,” said psychiatrist Sonia Dollfuss, emphasizing the “extremely rare” nature of the work.

For the majority of schizophrenics, estimated by the World Health Organization to be one in 300 people worldwide, the disease poses a danger to the first sufferers, especially since the suicide rate among them is high (5%).

To a large extent, schizophrenia results in a wide range of disorders of varying severity from one patient to another, often leading to profound disruptions in personal and social life.

Treatment for this disease is also complex and usually combines medication, social rehabilitation assistance, and psychotherapy.

In this last case, follow-up has improved in recent decades, Murray says, pointing to a decline in psychoanalytic treatments considered ineffective or counterproductive in treating such psychotic disorders.

On the other hand, in the field of medicine, the situation has been the same for years. However, unlike other psychiatric disorders, particularly neurological disorders, medication is the cornerstone of psychotherapy for schizophrenia.

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However, “after the vacuum starting from the second decade of the current century, when the laboratories really stopped their investments in psychiatry (…), a real innovation trend is currently registered,” Dollfuss says.

The “hopeful” path

At present, concrete innovations are related to follow-up of patients, for example, the development of computer applications that facilitate communication with a psychiatrist and the pattern of taking medications that are already known.

So, in April, the US health authorities approved the treatment developed by the Israeli company “Teva” and the French “Metensil”. The molecule, first known to psychiatrists, is given by injection rather than orally.

Thus, the drug can be gradually released into the body over a few weeks, rather than requiring daily intake.

The challenge is to allow better monitoring of medications when many patients are forced to stop their regular treatment due to their disorders. According to various sources, this was the case with the attacker in Reims.

Although this is a promising improvement at the therapeutic level, we cannot talk about a revolution associated with the appearance of new molecules. But in this area too, progress finally seems possible.

“Drugs that are currently being investigated are very interesting because of their new activity,” Dollfuss explains.

The molecules currently used in schizophrenia basically boil down to one mode of action: they block the activity of dopamine, a molecule that has a central effect on the nervous system.

However, dopamine appears to play a complex role in schizophrenia—whether it’s too much in some cases or not enough in others—and these treatments, which are very effective against symptoms like hallucinations, don’t improve other aspects of the disease, like loss. preference or language..

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In the face of this observation, research is finally focusing on other molecules whose mode of action is broader by regulating dopamine transmission, rather than inhibiting dopamine transmission, while acting in parallel with other potential molecules in schizophrenia disorders.

With no immediate marketing in mind, research on these treatments, which specifically target a protein called TAAR1, is at an advanced stage: large-scale studies called “Phase III” are beginning. Record good results.

“It’s a very promising path,” Dollfuss concludes.

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Scientists are tracking a tree in Brazil that was thought to have died out 185 years ago



Scientists are tracking a tree in Brazil that was thought to have died out 185 years ago

I retired at 100… A centenarian talks about the importance of “being busy at work” to live a long life.

Madeleine Balto recently retired at the age of 100, having worked for more than 80 years – from the age of 18 to 99. According to a CNBC report, Balto believes work has contributed to his longevity.

Balto says of his previous job: “It kept me busy, and I enjoyed the work… As for retirement, I don’t really like it.”

The Balto family started an electric sign manufacturing business in Chicago, with Madeline responsible for office work. She often interacted with customers and it was her favorite job.

She said: “I loved interacting with people… and I was the only one in the office doing all the office work, so it was fun.” “I loved going to work.”

An 85-year-old Harvard University study found that positive relationships make people happier and help them live longer. For this reason, it is not surprising that Balto places a strong emphasis on the importance of family and friends.

Assistant Professor of Medicine and Genetics and Director of Human Lifespan Studies at the Albert Einstein Institute for Aging Research, Dr. Sophia Melman says. College of Medicine.

At 100, Balto maintains his sense of community by going out to dinner with his sons and attending family events. Finally attended a wedding earlier this month.

She also likes going to the Dunkin’ Donuts branch every Sunday with her son to meet friends. “I look forward to it every week,” he says.

Balto affirms that she is lucky; Because she has some friends of the same age who often come to her house for lunch.

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She added: “They always invite me over and come over for lunch on Wednesdays at 12pm… we have fun together… without your friends, where are you, right?”

While maintaining healthy relationships is an important factor in living longer, there are other factors that contributed to Balto’s longevity.

First, Mellman says, “In general, women’s life expectancy is longer than men’s…and we believe that genetics also has a significant relationship with longevity.”

In fact, Balto’s older sister lived to be 103 years old. “But she and I are the only ones who lived over 100 years,” she says, referring to her parents, who died at 84, and her sisters, who didn’t live very long.

I grew up on a vegetarian diet

Aiming to stay active, Balto says, “I’m still getting around better. I can walk up the stairs. I have energy; “so I’m in pretty good shape.”

She also tries to eat as healthy as possible, something that started in her childhood, she explains: “When I was a child, there were seven children in the family, and my father was building a big garden, so we lived mostly. On vegetables. “There wasn’t a lot of meat, we couldn’t afford meat.”

“I think that’s probably why I eat healthier,” she adds. Don’t eat fast food now.

Millman says centenarians are generally more confident, and Balto fits that description. He says it’s unclear whether centenarians are always positive, or whether they develop their positive outlook as they age.

Balto says she doesn’t feel too nervous; Because “everything can be solved.” She continues: “I’m very lucky; As I am 100 years old, I am in good health… I cannot complain about my health. “I’m walking, talking, no pain.”

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Jordanian woman with cancer during pregnancy gives birth in Abu Dhabi



Jordanian woman with cancer during pregnancy gives birth in Abu Dhabi

Despite being diagnosed with colon cancer in the sixth month of pregnancy, a 36-year-old Jordanian woman overcame the difficulties and pains and gave birth to a healthy baby at Abu Dhabi – Burjeel Hospital. Rania Fuad Al-Sheikh suffered from severe abdominal pain throughout her pregnancy and as the weeks went by, her condition worsened and she became bedridden. Rania said: “When I found out I was going to be a mother for the second time, I felt it. Was very happy, but as my pregnancy progressed, I started suffering from severe pain and heaviness. “In my stomach and liver, in the sixth month of pregnancy, I was tired and had no appetite for food. I was transferred to the emergency room at Barjeel Hospital” Rania added: “I thanked God Almighty because we finally knew the cause of the pain and I was not sad because everything that comes from God is good. I wanted my baby to be healthy.”

Dr Muhannat Diab, an oncologist at Burjeel Hospital in Abu Dhabi, said: When Rania first arrived in April, she was unable to move or speak because biopsies revealed an aggressive form of colon cancer called mucinous adenocarcinoma. While the patient was in critical condition, further tests showed that the child’s condition was unstable, and realizing the seriousness of the situation, the hospital’s multidisciplinary team came up with a comprehensive chemotherapy plan. When the patient was 26 weeks pregnant, after three days of chemotherapy, the patient was able to move and was discharged from the hospital a week after the first chemotherapy session. She continued to have weekly medical appointments during which the team monitored her. Until the baby is born. In the 35th week of her pregnancy, Rania completed five rounds of chemotherapy, underwent a caesarean section, and delivered her little boy weighing 2.32 kilograms.

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The social consequences of the Al Hauz earthquake go beyond the economic damage



The social consequences of the Al Hauz earthquake go beyond the economic damage

We read some newspaper articles on Friday and the weekend, starting with “Al-Ilm”, which confirms that the earthquake that hit the Kingdom on September 8 may have social consequences, Ali Al-Shabani, a professor of sociology research. Going beyond economic and material damage, family structures are damaged when a family member dies, especially a parent, whose loss affects children and the family, contributing to the disintegration of the social fabric.

With the same media platform, the Regional Directorate of Equipment, Transport, Logistics and Water in Chichawa has taken several measures that made it possible to record the smooth flow of traffic on the classified and unclassified roads connecting the regional communities. Many areas were damaged by the Al Hauz earthquake.

According to the same newspaper, Tawfiq Al-Qurashi, head of the basic equipment department of the Regional Directorate of Equipment and Water in Chichaoua, noted that the ministry has provided about 23 vehicles, including six from the private sector, in the region. Opened 14 classified and unclassified roads and recorded smooth passage of relief convoys.Rescue teams to affected areas.

“Al-Alm” and several Moroccan economists reported that the cost of reconstruction did not exceed 5 percent of GDP. The Al Houze earthquake, although it was a humanitarian disaster, left scars in the region. And throughout Morocco, it may be an economic opportunity to start a new phase in dealing with the situation. With the rural world, it has been outside the orbits of development for decades.

The same newspaper wrote that Moroccan and foreign engineers and experts call for the preservation of historical and cultural elements in the reconstruction. Aziz Al Hilali, Chairman of the Association of Independent Engineers, said that the most difficult thing in this situation is the successful reconstruction and return to normal life. In the same context, the architects cautioned about the locations of some tents that serve as temporary shelters for residents and that they should not be installed in areas exposed to waterways or landslides.

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Also, to “Bayan al-Youm” published that the primary court in Marrakesh decided to postpone the consideration of the file in which the head of the Harbil Tamansoort group and an employee of the same group were arrested for fraud, participation in it, and forging a document issued by the public administration and using it for bribery until September 25. buying Preparation of defense and review of file documents is ongoing.

The court ruled to deny the defendants provisional release, after the session was concluded, after their side submitted a motion on the matter.

The same newspaper reported that the regional governor of cultural heritage of Beni Mellal-Kenifra region, Mohamed Choukry, said that the historical monuments in Ajilal province were not seriously damaged by the earthquake in Morocco on September 8. Shukri pointed out that the Al Hauz earthquake affected ancient local buildings, stressing that these buildings are known for their architectural characteristics that reflect the identity and history of the Middle High Atlas.

As for the “Socialist Union”, the National Union of Mothers and Fathers of Moroccan Students in Ukraine has written to the government and requested intervention to help the students. The association hopes to intervene through the Moroccan embassy in Ukraine to overcome difficulties and provide the students with the necessary support in their daily affairs, expressing confidence in the good understanding of the relevant ministers and their interest in its issues. sons and daughters.

In the material of the same newspaper, the news of the postponement of the 13th session of the Rachidia Film Festival, the session of director Hisham Al-Azri, which was scheduled to be organized from October 17 to 21, 2023. , as an expression of sympathy and solidarity with the victims and their families.

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