An international team led by researchers at the British Wellcome Sanger Institute has revealed a new drug target that could act as an alternative treatment for kidney cancer if doctors don’t recommend surgery. According to the results of a study published in the journal Nature Communications (Monday), this rare cancerous form of kidney tumor is called Renin tumor, and its complete genetic code has been understood for the first time.

Reninoma is one of the rarest cancers in humans, with only about 100 cases reported worldwide. Although it can usually be treated with surgery, it can cause severe high blood pressure and develop into malignant tumors that can spread.

There are still no medical treatments for kidney tumors, as treatment management only involves surgery. Before the results of the latest study came out, it was not known what genetic error caused these types of tumors.

According to the study’s co-principal investigator, Dr. Sam Bagadi, Wellcome Senior Research Fellow at the Wellcome Sanger Institute: “The significance of our results is that we have succeeded in discovering the essence of this type of tumor. Based on the fact that it is so rare, there have been no previous studies on it.

He added to Asharq Al-Awsat: “Not only have we been able to understand the genetic code of a kidney tumor, but we have also shown that drugs can counteract what triggers it, and this may be important for patients whose tumors cannot be removed. through surgery.”

Researchers have identified a specific error in the genetic code of a known cancer gene called NOTCH1, which is behind the development of this rare cancer.

“This is the first time we have identified the causes of kidney tumors, and we believe our work will continue to pave the way for new treatments,” said lead study author Taryn Trescher at the Wellcome Sanger Institute.

The team has already studied two cancer samples, one from a young adult and the other from a child, using advanced genetic techniques. Their findings suggest that existing drugs that actually target this gene could be used as a potential solution for treating kidney tumors in patients for whom surgery is not a viable option.

Dr Tansina Chowdhury, lead researcher on the study at Great Ormond Street Hospital in the UK, explained: “Rare forms of kidney cancer known as renal tumors do not respond to traditional anti-cancer treatments. “Currently the only known treatment is surgery.” She added: “There is a specific, well-known gene that drives this rare cancer. Our study shows that the studied gene has “If we use drugs that are already known to affect this gene, we can deal with it without the need for invasive medical technology like surgery.”

Here Bahjati said: “Rare cancers are a huge challenge for research and analysis. Patients with other types of tumors may not benefit from them. “But here is a powerful example of cutting-edge science that is changing our understanding of an extremely rare type of tumor: a discovery that could have immediate clinical benefits for patients.” He added: “We will continue to study these extremely rare tumors to understand their genetic code, which we hope will reveal more new therapeutic approaches.”

September 24, 2023

Breast cancer is a disease that affects women, especially with a high number of infections, but in fact it affects men as well, and many believe that it leads to death among them.

she explained NHS The NHS in England says that 85 men die each year in Britain from breast cancer, and that the malignancy affects around 400 men annually.

The charity Breast Cancer Now also reports that “at least one person is diagnosed with the disease every day”.

According to the website “Mayo ClinicMedically, male breast cancer is “a rare cancer that begins with the growth of cells in the breast tissue of men.”

“Breast cancer in men usually affects older people, but it can occur at any age,” he pointed out.

Those diagnosed with “male breast cancer” at an early stage have a good chance of recovery.

What are the symptoms?

The symptoms of this disease are as follows:

A painless lump or thickening of breast tissue and changes in the skin of the breast, such as sagging, wrinkling, redness or peeling.
Changes in the nipples, such as redness or peeling, or one of the nipples turning inward.

The causes of these malignant tumors are still unclear, but doctors define “male breast cancer” as occurring when “some breast cells divide faster than healthy cells.”

Accumulated cells form a tumor, which can spread (metastasize) to nearby tissues, lymph nodes, or other parts of the body.

According to the website “Web MedicineThe disease can be diagnosed through a clinical examination, which is done by feeling the chest area of ​​the person in search of any tumors or changes in the chest tissue, and the doctor evaluates the size, structure and depth of the tumors present.

It can be diagnosed with radiographic imaging such as X-rays or ultrasound to create clear images of the breast tissue.

Only a biopsy is used to “confirm” a diagnosis of breast cancer in men. This is done by taking a sample of the tumor tissue and examining it to confirm whether the tumor is cancerous or benign.

Treatment usually involves surgery to remove as much of the visible tumor as possible, along with some of the surrounding healthy tissue.

Other treatments such as chemotherapy and radiotherapy may be recommended depending on the condition.