science
Study.. Breakthrough in brain cancer treatment
An experimental oral drug significantly delayed the growth of a malignant brain tumor, a major breakthrough in treating brain cancers that have progressed poorly for decades and have a high rate of disability and early death.
showed study Patients with grade 2 gliomas who took vorazidenib from Servier Pharmaceuticals after surgery and before chemotherapy or radiation therapy reported significant improvement Sunday in the New England Journal of Medicine.
According to the study, the growth and development of cancer cells was twice as delayed compared to patients who did not take this drug.
By delaying tumor growth, the study showed the drug also extended the time patients, who are often healthy young adults, had to wait before starting chemotherapy and radiation.
Therefore, the study suggests that the drug may help delay cognitive decline, memory loss, and other side effects that can accompany metastatic brain cancer.
The drug, the study showed, acts as an inhibitor of two enzymes, IDH1 and IDH2, which show early activity in mutant IDH gliomas, and the drug penetrates the tumor site through the blood-brain barrier.
According to the study, gliomas are the most common malignant primary brain tumors in adults and are classified by the World Health Organization (WHO) into different tumor subtypes and tumor grades according to different histological and molecular features.
The study showed that IDH1 and IDH2 enzymes were present in almost all metastatic grade II gliomas in adults.
According to the study, more than 80 percent of grade II glioma patients have cancers with mutations in a gene called IDH that promotes tumor growth.
The study shows that most drugs cannot cross the protective layer of vessels and tissues called the blood-brain barrier, and the small number of affected patients makes it difficult to conduct large trials.
In the trial, 331 patients with malignant grade II glioma had some residual tumor tissue or relapsed after surgery. Patients from 77 health centers in 10 countries participated.
About 168 patients took the drug as a daily pill, while about 163 patients took a placebo.
Patients who took the experimental drug had a median cancer-free survival of 28 months, compared with 11 months for patients who took a placebo.
Within two years, the probability of not needing additional treatment was about 83 percent for patients taking the drug, compared to 27 percent for patients taking the placebo.
To treat grade II gliomas, doctors typically surgically remove as much of the cancer as possible, the study indicates. Then they monitor the growth of the tumors or treat them with chemotherapy and radiation, but these tumors are incurable and sometimes come back after a few years.
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science
Scientists are tracking a tree in Brazil that was thought to have died out 185 years ago
I retired at 100… A centenarian talks about the importance of “being busy at work” to live a long life.
Madeleine Balto recently retired at the age of 100, having worked for more than 80 years – from the age of 18 to 99. According to a CNBC report, Balto believes work has contributed to his longevity.
Balto says of his previous job: “It kept me busy, and I enjoyed the work… As for retirement, I don’t really like it.”
The Balto family started an electric sign manufacturing business in Chicago, with Madeline responsible for office work. She often interacted with customers and it was her favorite job.
She said: “I loved interacting with people… and I was the only one in the office doing all the office work, so it was fun.” “I loved going to work.”
An 85-year-old Harvard University study found that positive relationships make people happier and help them live longer. For this reason, it is not surprising that Balto places a strong emphasis on the importance of family and friends.
Assistant Professor of Medicine and Genetics and Director of Human Lifespan Studies at the Albert Einstein Institute for Aging Research, Dr. Sophia Melman says. College of Medicine.
At 100, Balto maintains his sense of community by going out to dinner with his sons and attending family events. Finally attended a wedding earlier this month.
She also likes going to the Dunkin’ Donuts branch every Sunday with her son to meet friends. “I look forward to it every week,” he says.
Balto affirms that she is lucky; Because she has some friends of the same age who often come to her house for lunch.
She added: “They always invite me over and come over for lunch on Wednesdays at 12pm… we have fun together… without your friends, where are you, right?”
While maintaining healthy relationships is an important factor in living longer, there are other factors that contributed to Balto’s longevity.
First, Mellman says, “In general, women’s life expectancy is longer than men’s…and we believe that genetics also has a significant relationship with longevity.”
In fact, Balto’s older sister lived to be 103 years old. “But she and I are the only ones who lived over 100 years,” she says, referring to her parents, who died at 84, and her sisters, who didn’t live very long.
I grew up on a vegetarian diet
Aiming to stay active, Balto says, “I’m still getting around better. I can walk up the stairs. I have energy; “so I’m in pretty good shape.”
She also tries to eat as healthy as possible, something that started in her childhood, she explains: “When I was a child, there were seven children in the family, and my father was building a big garden, so we lived mostly. On vegetables. “There wasn’t a lot of meat, we couldn’t afford meat.”
“I think that’s probably why I eat healthier,” she adds. Don’t eat fast food now.
Millman says centenarians are generally more confident, and Balto fits that description. He says it’s unclear whether centenarians are always positive, or whether they develop their positive outlook as they age.
Balto says she doesn’t feel too nervous; Because “everything can be solved.” She continues: “I’m very lucky; As I am 100 years old, I am in good health… I cannot complain about my health. “I’m walking, talking, no pain.”
“Award-winning beer geek. Extreme coffeeaholic. Introvert. Avid travel specialist. Hipster-friendly communicator.”
science
Jordanian woman with cancer during pregnancy gives birth in Abu Dhabi
Despite being diagnosed with colon cancer in the sixth month of pregnancy, a 36-year-old Jordanian woman overcame the difficulties and pains and gave birth to a healthy baby at Abu Dhabi – Burjeel Hospital. Rania Fuad Al-Sheikh suffered from severe abdominal pain throughout her pregnancy and as the weeks went by, her condition worsened and she became bedridden. Rania said: “When I found out I was going to be a mother for the second time, I felt it. Was very happy, but as my pregnancy progressed, I started suffering from severe pain and heaviness. “In my stomach and liver, in the sixth month of pregnancy, I was tired and had no appetite for food. I was transferred to the emergency room at Barjeel Hospital” Rania added: “I thanked God Almighty because we finally knew the cause of the pain and I was not sad because everything that comes from God is good. I wanted my baby to be healthy.”
Dr Muhannat Diab, an oncologist at Burjeel Hospital in Abu Dhabi, said: When Rania first arrived in April, she was unable to move or speak because biopsies revealed an aggressive form of colon cancer called mucinous adenocarcinoma. While the patient was in critical condition, further tests showed that the child’s condition was unstable, and realizing the seriousness of the situation, the hospital’s multidisciplinary team came up with a comprehensive chemotherapy plan. When the patient was 26 weeks pregnant, after three days of chemotherapy, the patient was able to move and was discharged from the hospital a week after the first chemotherapy session. She continued to have weekly medical appointments during which the team monitored her. Until the baby is born. In the 35th week of her pregnancy, Rania completed five rounds of chemotherapy, underwent a caesarean section, and delivered her little boy weighing 2.32 kilograms.
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science
The social consequences of the Al Hauz earthquake go beyond the economic damage
We read some newspaper articles on Friday and the weekend, starting with “Al-Ilm”, which confirms that the earthquake that hit the Kingdom on September 8 may have social consequences, Ali Al-Shabani, a professor of sociology research. Going beyond economic and material damage, family structures are damaged when a family member dies, especially a parent, whose loss affects children and the family, contributing to the disintegration of the social fabric.
With the same media platform, the Regional Directorate of Equipment, Transport, Logistics and Water in Chichawa has taken several measures that made it possible to record the smooth flow of traffic on the classified and unclassified roads connecting the regional communities. Many areas were damaged by the Al Hauz earthquake.
According to the same newspaper, Tawfiq Al-Qurashi, head of the basic equipment department of the Regional Directorate of Equipment and Water in Chichaoua, noted that the ministry has provided about 23 vehicles, including six from the private sector, in the region. Opened 14 classified and unclassified roads and recorded smooth passage of relief convoys.Rescue teams to affected areas.
“Al-Alm” and several Moroccan economists reported that the cost of reconstruction did not exceed 5 percent of GDP. The Al Houze earthquake, although it was a humanitarian disaster, left scars in the region. And throughout Morocco, it may be an economic opportunity to start a new phase in dealing with the situation. With the rural world, it has been outside the orbits of development for decades.
The same newspaper wrote that Moroccan and foreign engineers and experts call for the preservation of historical and cultural elements in the reconstruction. Aziz Al Hilali, Chairman of the Association of Independent Engineers, said that the most difficult thing in this situation is the successful reconstruction and return to normal life. In the same context, the architects cautioned about the locations of some tents that serve as temporary shelters for residents and that they should not be installed in areas exposed to waterways or landslides.
Also, to “Bayan al-Youm” published that the primary court in Marrakesh decided to postpone the consideration of the file in which the head of the Harbil Tamansoort group and an employee of the same group were arrested for fraud, participation in it, and forging a document issued by the public administration and using it for bribery until September 25. buying Preparation of defense and review of file documents is ongoing.
The court ruled to deny the defendants provisional release, after the session was concluded, after their side submitted a motion on the matter.
The same newspaper reported that the regional governor of cultural heritage of Beni Mellal-Kenifra region, Mohamed Choukry, said that the historical monuments in Ajilal province were not seriously damaged by the earthquake in Morocco on September 8. Shukri pointed out that the Al Hauz earthquake affected ancient local buildings, stressing that these buildings are known for their architectural characteristics that reflect the identity and history of the Middle High Atlas.
As for the “Socialist Union”, the National Union of Mothers and Fathers of Moroccan Students in Ukraine has written to the government and requested intervention to help the students. The association hopes to intervene through the Moroccan embassy in Ukraine to overcome difficulties and provide the students with the necessary support in their daily affairs, expressing confidence in the good understanding of the relevant ministers and their interest in its issues. sons and daughters.
In the material of the same newspaper, the news of the postponement of the 13th session of the Rachidia Film Festival, the session of director Hisham Al-Azri, which was scheduled to be organized from October 17 to 21, 2023. , as an expression of sympathy and solidarity with the victims and their families.
“Award-winning beer geek. Extreme coffeeaholic. Introvert. Avid travel specialist. Hipster-friendly communicator.”
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