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Scientists have developed a new vaccine that protects against Lyme disease using mRNA technology

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Scientists have developed a new vaccine that protects against Lyme disease using mRNA technology


Written by Amal Allam

Tuesday, October 17, 2023 03:52 PM

Scientists in the US have developed a vaccine to protect against Lyme disease, an infection spread by the bite of an infected tick, to prevent the bacteria that cause it..


A new vaccine for Lyme disease

According to the British Daily Mail website, Lyme disease affects around 3,000 people in the United Kingdom each year, although the association Lyme disease activity The charity estimates the true number is closer to 15,000, as many affected people do not seek medical help for symptoms such as joint pain and fever, which can cause the disease..

The disease is caused by the bite of a tick infected with the bacteria Borrelia burgdorferi, which is usually contracted when they feed on other animals – especially rodents – that carry the bacteria..

Cases of Lyme disease in the UK have increased about 10-fold since 2000, largely because milder winters have allowed ticks to thrive, the newspaper said.

Symptoms like fatigue and…Arthritis and muscle aches, headache, fever and neck stiffness Two to 30 days later, one of the earliest symptoms is the appearance of a spot-shaped rash, which indicates that bacteria from the tick has spread to the bite area.

Antibiotics given immediately can stop the spread of the bacteria, but because the tick is so small, many people don’t realize they’ve been bitten. If the infection is not treated, it can lead to neurological problems (including numbness in the hands and feet), and fatigue, chronic, memory loss, difficulty concentrating and heart rhythm disorders, which require medication and are used as vaccines. mRNA The genetic material from the bacteria tells the body’s cells to produce a specific protein, which the immune system detects when it is defective. It is faster and cheaper to produce than traditional vaccines and does not use live viruses like many existing vaccines. ..

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The Lyme vaccine uses genetic material from a protein found in bacteria called outer surface protein A Or OspA Once the immune system interacts with this genetic material, it begins to produce infection-fighting cells that can then get rid of the disease, most importantly, the protein. OspA It is present in all strains of Borrelia burgdorferi (there are at least 18), which means the vaccine is effective against all of them..

Blood samples taken from the vaccinated mice showed they were still enjoying a high level of protection even 6 months after a single dose, according to results published in the journal. Cellpress In the month of August.

Researchers now hope to reproduce the results in clinical trials involving human volunteers. Meanwhile, Moderna is working Moderna Recruit 800 volunteers for vaccine trial mRNA For Lyme disease, the first results are expected in 2026.

Rival Pfizer is developing a vaccine for Lyme disease, made from cells taken from the harmful bacteria — a more traditional method — that will be available within the next three years..

Commenting on the latest results, Professor Hani Al-Sheikha, a veterinary parasitologist at the University of Nottingham, said: “The results are encouraging, but it is still too late to translate the results into a human vaccine.” A new vaccine is a type of vaccine. mRNAMade using the same cutting-edge technology used to make Moderna and Pfizer’s anti-coronavirus drugs. Pfizer/BioEntech AndModerna.



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The most dangerous of them is the “breath of the dead” … Bad breath is a symptom of these serious diseases

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The most dangerous of them is the “breath of the dead” … Bad breath is a symptom of these serious diseases

Some metabolic disorders can cause bad breath due to various problems in the intestines, blood or liver.

The following are the most important medical conditions that can cause complications:

diabetes

  • A common condition that causes bad breath in the mouth and throat is diabetes because high glucose levels can cause the growth of harmful bacteria.
  • Because people with diabetes have insulin problems, cells may not get the glucose they need for energy, and instead the body starts burning fat-forming compounds called ketones.
  • Ketones accumulate in the blood and urine and cause bad breath.
  • One of these ketones is acetone, and it can cause breath to smell like nail polish.
  • If someone with diabetes notices the smell, they should seek medical advice as it could be due to diabetic ketoacidosis, a life-threatening condition.

Liver disease

  • If a person’s breath has a strong, foul smell, this is a sign that the liver is not filtering out toxins.
  • Doctors call this distinctive smell “the breath of the dead” because of its association with severe and fatal liver disease.

Kidney disease

  • Chronic kidney disease is a condition in which the kidneys are damaged and cannot filter the blood properly, which is why excess fluids and waste from the blood can build up in the body and cause other health problems such as heart disease and stroke.
  • People with kidney failure may develop bad breath.
  • As the kidneys begin to fail, the metabolic urea cannot be excreted effectively in the urine, and it accumulates in the blood and saliva.
  • The body converts urea into ammonia, which causes bitterness in the mouth and bad breath.
  • One in three people on dialysis say their breath smells like urine.
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Too much methionine in the blood

  • It is an increase in a specific protein building block (amino acid) called methionine in the blood.
  • People with this condition often have no symptoms, but if their breath, sweat, or urine smells like boiled cabbage, they should see a doctor.

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Head of State: We are interested in international cooperation to achieve the success of the goals of “COP28”.

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Head of State: We are interested in international cooperation to achieve the success of the goals of “COP28”.

The Head of State Sheikh Mohammed bin Zayed Al Nahyan attended some of the “Group of 77 and China” meetings held during the proceedings of the Conference of the Parties to the United Nations. Framework Conference on Climate Change (COP28), which is taking place at Expo City Dubai.

While attending the meeting, he welcomed the participating leaders and emphasized the importance of cooperation among developing countries to promote their common interests and to ensure their presence in international affairs, embodied in the meetings of the group.

His Highness emphasized the UAE’s interest in strengthening international cooperation to achieve the success of the goals of the 28th session of the Conference of the Parties in accelerating the transition towards a sustainable, low-carbon, high-growth economic model through effective detection. Action-based solutions to the climate crisis facing the world.

For their part, participants appreciated the UAE’s hosting of the first-ever group meetings at COP conferences, noting that the meetings provided an opportunity to discuss areas of common interest, identify common challenges and propose measures to address them. Confront team members while emphasizing the importance of teamwork and cooperation.

During the World Climate Action Summit, the leaders also appreciated the announcement of the President of the State, emphasizing the importance of this initiative in supporting the path of sustainable development and promoting sustainable development globally. Based on international cooperation.

They also emphasized the importance of the “COP28” agenda, which aims to catalyze collective action to protect ecosystems and food systems that are resilient to climate change, empowering the most affected communities by investing in practical solutions to improve lives and livelihoods. .

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Muhammad bin Saeed:

• Finding effective solutions to the global climate crisis.

• Accelerating the transition towards a sustainable economic model.

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Amiri Diwan confirms stability of Kuwait Emir’s health… And prosecution threatens to prosecute those who spread rumors about “the arrangement of the ruling house”.

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Amiri Diwan confirms stability of Kuwait Emir’s health… And prosecution threatens to prosecute those who spread rumors about “the arrangement of the ruling house”.

United Arab Emirates (CNN) — Kuwaiti Emir Sheikh Nawaf Al-Ahmad Al-Jaber Al-Sabah’s health condition was confirmed on Saturday by the Minister of Emirati Diwan Affairs, Sheikh Muhammad Al-Abdullah Al-Sabah. It is stable, thanks to God Almighty,” Kuwait News Agency reported. “Kona.”

The minister added: “We pray to the Almighty God for a speedy recovery to the Emir of the country and to grant him good health and complete well-being.”

The Minister of Amiri Diwan Affairs said on Wednesday that the health of the Emir of Kuwait is stable and he is still receiving the necessary treatment.

Earlier, the Amiri Diwan minister said the Kuwaiti emir “entered the hospital to receive treatment and undergo a medical examination following a health condition”.

For its part, the Kuwaiti Public Prosecution warned in a statement on Saturday against “taking decisive action and filing criminal charges against every individual, group, platform, media, radio station or any organization that publishes or addresses anything related to the health of the Emir or the arrangement of the ruling house.”

The Kuwait Public Prosecution added: “We have been monitoring many false reports and shocking lies in the media, and by individuals on visual, audio and print media platforms, about the health of the Emir of the country or the arrangements of the ruling house. According to Kuna.

Rumor mongers have used the word as a weapon to spread poison in the society using flimsy pretexts of freedom of expression, good intentions and fear, forgetting the harmful effects of rumours. According to the Kuwaiti Agency, there is more than a raging plague.

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