June 6, 2023

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The good news for diabetes ... the treatment of regenerating insulin cells

The good news for diabetes … the treatment of regenerating insulin cells

A growing way to treat diabetes is to repair or replace cells in the body that naturally produce insulin.

In this field, Swedish researchers have identified a molecule that helps stimulate the growth of new insulin-producing cells.

They also discovered the mechanism of action of the new division in the pancreas, which reveals the possibility of achieving a new possible treatment for diabetes.

Cells in the pancreas

According to New Atlas, citing Nature Chemical Biology, diabetes is caused by problems with insulin secretion, which regulates blood sugar levels and allows the body’s cells to access it for energy.

In type 1 diabetes, the beta cells in the pancreas that normally produce insulin cannot meet the requirement because the cells are destroyed by the immune system.

Although current treatment relies on the administration of insulin injections, the growing branch of the study focuses on finding ways to regenerate insulin production through beta cells.

Previous research may have involved the development of synthetic beta cells, either to compensate for defects caused by normal cell degeneration or to use stem cells to grow new beta cells.

Small molecule

In a new study, researchers at the Karolinska Institutet in Sweden studied a small molecule that helps regenerate beta cells.

The molecule, called CID661578, was identified in a previous research effort, but it is not known how and to what extent it works.

To answer those questions, the researchers studied molecular relationships in beta cells and discovered that they bind to a protein called MNK2.

It has been shown that when the other two proteins are allowed to interact at high levels, it eventually leads to increased beta cell renewal.

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Promising results

The researchers conducted experiments to stimulate the molecular reaction in zebrafish and laboratory animals, and found that it lowers blood sugar levels compared to a control group and leads to the formation of new beta cells.

At the same time, when experiments were performed on molecularly supplied human pancreatic organs, they produced more insulin.

It is noteworthy that the results of the study indicate a new potential goal for the treatment of diabetes.

The authors said they had found a possible way to stimulate the formation of new insulin-producing cells because the team is currently studying the effect of this new area and similar molecules in human tissues and analyzing the target protein of the MNK2 molecule in tissues. From healthy donors and diseased donors.