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Does a booster dose of Omicron help prevent re-infection?



Does a booster dose of Omicron help prevent re-infection?

It appears that those who received booster vaccines are more likely to be reinfected with the mutated coronavirus than those who received the initial series of vaccines.

That’s the conclusion of a recent statistical study conducted by Hiam Al-Shamitali, PhD, in epidemiology and population health at Weill Cornell Medicine in Qatar – the Infectious Disease Epidemiology Group and his colleagues, published on October 4, 2023, in the journal Science Advances. .

Success of vaccines against the first strain

In 2022, the Covid-19 pandemic was brought under control, and the World Health Organization declared it a global health emergency on May 5, 2023. This success is largely due to the rapid development and distribution of effective vaccines for SARS-CoV-2. Some of these vaccines have shown more than 90 percent effectiveness in trials. By 2021, widespread immunity to the original virus strain was achieved through global vaccination efforts.

“Omicron” bypasses acquired immunity

However, by the end of 2021, a highly infectious “Omicron” variant appeared and was genetically different from the original strain. Omicron’s ability to evade immune responses trained to the original virus led to its rapid spread even among vaccinated individuals, and it became clear that existing vaccines were less effective against Omicron. The strains of the virus are new.

Injury data analysis study

The study analyzes population health data from Qatar to investigate epidemiological evidence for such an immune signature. The Omicron variant compared the risk of reinfection after a previous infection among populations with a different history of mRNA vaccination prior to any documented natural infection.

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The study compared the risk of reinfection with Omicron among three groups: those who were not vaccinated, those who received two doses of the vaccine, and those who received a booster dose after two doses.

The researchers followed the individuals over time, starting three months after the initial infection with Omicron. They found that those who received two doses of the vaccine had a lower risk of reinfection.

High risk of infection

However, those who received a booster dose were about 50 percent more likely to become infected again compared to those who received two doses, suggesting a greater risk of reinfection in individuals vaccinated with a booster dose.

Compared to those who received three doses, it appeared that people who received two doses of the vaccine may have better immunity to Omicron because those who received two doses appeared to have fewer immune events as a result of the vaccine, allowing them to mount. A high immune response is effective against “Omicron”.

Therefore, giving booster doses may not be beneficial and may even be harmful in some cases.

Questions about the results of the study

However, the study results should be interpreted with caution. It is worth noting that the study design has limitations.

Some experts said the comparison between the three-dose and two-dose groups was biased because those in the three-dose group received a booster shot shortly before exposure to Omicron, making them more susceptible to infection.

In contrast, individuals who received two doses received their initial vaccination, so the protective effect may have been reduced. Therefore, because the two-dose group represents a broader portion of the population, the study’s assumption that these two groups are similar in terms of the likelihood of relapse is questionable.

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Difficulty evaluating results accurately

For his part, Christian Hansen, Associate Professor of the Department of Epidemiology of Infectious Diseases at the London School of Hygiene and Tropical Medicine, London, said in his research published in the same journal on October 4 this year. , he has a different opinion. He says it is difficult to accurately assess the impact of various biases that may have affected the results of the studies conducted by Hiam Al-Shemaitli and his team.

In observational studies of vaccine efficacy, comparisons of infection rates are valid in the short period after vaccination, but over time the effects of selection and other biases increase, affecting over time. Patterns observed long after vaccination. Researchers in the study determined the infection rates by analyzing the results of the “SARS Cove 2” trial from national databases, because these infection rates are not only affected by the actual infection in the comparison groups, but also by the tests. Behaviors that differ between groups and change over time.

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Amiri Diwan confirms stability of Kuwait Emir’s health… And prosecution threatens to prosecute those who spread rumors about “the arrangement of the ruling house”.



Amiri Diwan confirms stability of Kuwait Emir’s health… And prosecution threatens to prosecute those who spread rumors about “the arrangement of the ruling house”.

United Arab Emirates (CNN) — Kuwaiti Emir Sheikh Nawaf Al-Ahmad Al-Jaber Al-Sabah’s health condition was confirmed on Saturday by the Minister of Emirati Diwan Affairs, Sheikh Muhammad Al-Abdullah Al-Sabah. It is stable, thanks to God Almighty,” Kuwait News Agency reported. “Kona.”

The minister added: “We pray to the Almighty God for a speedy recovery to the Emir of the country and to grant him good health and complete well-being.”

The Minister of Amiri Diwan Affairs said on Wednesday that the health of the Emir of Kuwait is stable and he is still receiving the necessary treatment.

Earlier, the Amiri Diwan minister said the Kuwaiti emir “entered the hospital to receive treatment and undergo a medical examination following a health condition”.

For its part, the Kuwaiti Public Prosecution warned in a statement on Saturday against “taking decisive action and filing criminal charges against every individual, group, platform, media, radio station or any organization that publishes or addresses anything related to the health of the Emir or the arrangement of the ruling house.”

The Kuwait Public Prosecution added: “We have been monitoring many false reports and shocking lies in the media, and by individuals on visual, audio and print media platforms, about the health of the Emir of the country or the arrangements of the ruling house. According to Kuna.

Rumor mongers have used the word as a weapon to spread poison in the society using flimsy pretexts of freedom of expression, good intentions and fear, forgetting the harmful effects of rumours. According to the Kuwaiti Agency, there is more than a raging plague.

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After trying it…new anti-obesity drug alert



After trying it…new anti-obesity drug alert

However, Pfizer announced its intention to develop a modified version of the drug “Danoglipron”.

This drug belongs to a new class of successful treatments based on a component such as the gastrointestinal hormone glucagon or GLP-1 (GLP-1).GLP-1This leads to a feeling of fullness and weight loss.

“Danoglibron” differs from competing drugs already on the market in that it is not given by injection, but is given orally in the form of tablets.

During the clinical trial, Pfizer tested taking these pills twice a day, but said it wanted to focus on a new once-a-day formulation.

The clinical trial included a few hundred obese participants without type 2 diabetes.

Pfizer explained that the side effects in this trial were similar to those that can occur with this type of drug, but “it is noteworthy that their rates were high” because “cases of nausea reached 73 percent, vomiting reached 47 percent, and diarrhea reached 25 percent.”

More than half of the participants who received this drug discontinued treatment.

However, “Danoglipro” has been shown to lead to weight loss between 8 percent and 13 percent over 32 weeks or between 5 percent and 9.5 percent over 26 weeks.

A report quoted Pfizer senior executive Michael Tolston as confirming that “an improved once-daily formulation of tanoglipron could play an important role in the treatment of obesity.”

The highly lucrative anti-obesity drug market is currently dominated by the Danish “Novo Nordisk” group with its drug “Vecovi” and the American “Eli Lilly” company “Zebound”. America last month.

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5 Foods That Can Help You Stay Positive and Fight Depression, Especially Eggs



5 Foods That Can Help You Stay Positive and Fight Depression, Especially Eggs

By Anas al-Banna

Saturday, December 2, 2023 at 12:00 AM

With winter approaching and the seasons fluctuating, many are depressed, especially by things including rain and lack of sunrise, the website says “Health scenesWe show how diet can improve mental health and which foods can help manage it Depression By improving a person’s mood.

The connection between food and your mood

If you eat healthy, you will be healthy; Otherwise, you will have health problems, and when it comes to mental health, nutrition plays an important role.

Foods that help fight depression

Add these foods to your diet to fight depression:

1. Walnut

Walnuts are one of the most important nuts for brain health because they help improve cognitive health. Their high levels of antioxidants and vitamins improve mental alertness and fight depression..

2. Avocado

Avocados contain healthy fats that help improve cognitive function, memory, and concentration. Apart from that, avocados also contain tryptophan, which helps increase levels of serotonin, which is associated with the hormone of happiness.

3. Berry

The high levels of antioxidants in berries help protect the brain from stress, anxiety and depression, and have been shown to improve mood and cognition..

4. Broccoli

Broccoli helps keep the memory sharp due to its high amount of choline, and helps reduce depression and support a good mood. .

5. Eggs

Eggs are rich in choline, which is one of the most important neurotransmitters in managing stress and depression..

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