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UK gives green light to world-first CRISPR gene-editing therapy

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UK gives green light to world-first CRISPR gene-editing therapy

Dubai, United Arab Emirates (CNN) — The United Kingdom has become the first country to grant regulatory approval to a medical treatment involving the revolutionary gene-editing tool CRISPR.

The country’s Medicines and Healthcare products Regulatory Agency said on Thursday that it has been given the green light for the treatment of “Kaskevi”, which is used to treat sickle cell anemia and beta thalassemia. Both genetic conditions are caused by errors in the genes for hemoglobin, which red blood cells use to carry oxygen around the body. There is no universally known cure for either disease.

Sickle cell disease, which can lead to debilitating pain, is more common in people with African or Caribbean family roots. Beta thalassemia mainly affects people from the Mediterranean region, South Asia, Southeast Asia and the Middle East, the report said.

Julian Beach, interim chief executive of quality and access to healthcare at the Medicines and Healthcare products Regulatory Agency, said: “Sickle cell anemia and beta thalassemia are painful, life-long diseases, and in some cases can be fatal. A bone marrow transplant. A matched donor “closer and rejection. At risk, it remains the only permanent treatment option so far.”

He continued: “I am delighted to announce that we have received approval to use an innovative and first-of-its-kind gene-editing therapy, called CaskV, for beta thalassemia patients with sickle cell disease and an approved blood transfusion, reducing the symptoms of the disease.

CRISPR-Cas9… hope

CRISPR-Cas9 gene editing technology allows scientists to make very precise changes to DNA. Its two inventors, Emmanuel Charpentier and Jennifer A. Doudna, Nobel Prize in Chemistry 2020.

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And “Casgevy” treatment is not a simple pill or injection. The treatment, manufactured by Vertex Pharmaceuticals, involves taking stem cells from a patient’s bone marrow and modifying the genes in the cells in a laboratory. According to the Medicines and Healthcare Products Regulatory Agency, patients must undergo “conditioning therapy” that includes immunosuppressive drugs, radiation therapy or chemotherapy to prepare the bone marrow before the transplanted cells can be transplanted back into the patient.

The report added, “After that, patients will need to stay in the hospital for at least a month while the treated cells settle in the bone marrow and start producing red blood cells with stable hemoglobin.”

The US Food and Drug Administration is evaluating the same treatment and is expected to make a decision on whether or not to allow its use by December 8.

Alina Bans, a senior lecturer in genetics at the University of Hertfordshire, said in a statement released by the Center for Science Media, “This is a great advance in medical approaches to treating genetic diseases that we didn’t think were curable.”

Bans added, “Transplantation of stem cells from the patient’s bone marrow avoids the problems associated with immunocompatibility, that is, searching for donors who match the patient and pursuing immunocompetence, and is considered a real treatment of the disease and not a drug.”

The agency’s release did not specify the cost of the treatment, but it could be expensive.

CRISPR-Cas9 has had a major impact on biomedical research, clinical medicine, and agriculture, and is widely used in laboratories around the world.

The advanced technology sparked controversy after Chinese scientist He Jiankui announced in 2018 that he had created the world’s first genetically modified babies. Scientists say this powerful technique should not be used to manipulate human genes that are passed down from generation to generation.

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The most dangerous of them is the “breath of the dead” … Bad breath is a symptom of these serious diseases

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The most dangerous of them is the “breath of the dead” … Bad breath is a symptom of these serious diseases

Some metabolic disorders can cause bad breath due to various problems in the intestines, blood or liver.

The following are the most important medical conditions that can cause complications:

diabetes

  • A common condition that causes bad breath in the mouth and throat is diabetes because high glucose levels can cause the growth of harmful bacteria.
  • Because people with diabetes have insulin problems, cells may not get the glucose they need for energy, and instead the body starts burning fat-forming compounds called ketones.
  • Ketones accumulate in the blood and urine and cause bad breath.
  • One of these ketones is acetone, and it can cause breath to smell like nail polish.
  • If someone with diabetes notices the smell, they should seek medical advice as it could be due to diabetic ketoacidosis, a life-threatening condition.

Liver disease

  • If a person’s breath has a strong, foul smell, this is a sign that the liver is not filtering out toxins.
  • Doctors call this distinctive smell “the breath of the dead” because of its association with severe and fatal liver disease.

Kidney disease

  • Chronic kidney disease is a condition in which the kidneys are damaged and cannot filter the blood properly, which is why excess fluids and waste from the blood can build up in the body and cause other health problems such as heart disease and stroke.
  • People with kidney failure may develop bad breath.
  • As the kidneys begin to fail, the metabolic urea cannot be excreted effectively in the urine, and it accumulates in the blood and saliva.
  • The body converts urea into ammonia, which causes bitterness in the mouth and bad breath.
  • One in three people on dialysis say their breath smells like urine.
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Too much methionine in the blood

  • It is an increase in a specific protein building block (amino acid) called methionine in the blood.
  • People with this condition often have no symptoms, but if their breath, sweat, or urine smells like boiled cabbage, they should see a doctor.

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Head of State: We are interested in international cooperation to achieve the success of the goals of “COP28”.

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Head of State: We are interested in international cooperation to achieve the success of the goals of “COP28”.

The Head of State Sheikh Mohammed bin Zayed Al Nahyan attended some of the “Group of 77 and China” meetings held during the proceedings of the Conference of the Parties to the United Nations. Framework Conference on Climate Change (COP28), which is taking place at Expo City Dubai.

While attending the meeting, he welcomed the participating leaders and emphasized the importance of cooperation among developing countries to promote their common interests and to ensure their presence in international affairs, embodied in the meetings of the group.

His Highness emphasized the UAE’s interest in strengthening international cooperation to achieve the success of the goals of the 28th session of the Conference of the Parties in accelerating the transition towards a sustainable, low-carbon, high-growth economic model through effective detection. Action-based solutions to the climate crisis facing the world.

For their part, participants appreciated the UAE’s hosting of the first-ever group meetings at COP conferences, noting that the meetings provided an opportunity to discuss areas of common interest, identify common challenges and propose measures to address them. Confront team members while emphasizing the importance of teamwork and cooperation.

During the World Climate Action Summit, the leaders also appreciated the announcement of the President of the State, emphasizing the importance of this initiative in supporting the path of sustainable development and promoting sustainable development globally. Based on international cooperation.

They also emphasized the importance of the “COP28” agenda, which aims to catalyze collective action to protect ecosystems and food systems that are resilient to climate change, empowering the most affected communities by investing in practical solutions to improve lives and livelihoods. .

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Muhammad bin Saeed:

• Finding effective solutions to the global climate crisis.

• Accelerating the transition towards a sustainable economic model.

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Amiri Diwan confirms stability of Kuwait Emir’s health… And prosecution threatens to prosecute those who spread rumors about “the arrangement of the ruling house”.

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Amiri Diwan confirms stability of Kuwait Emir’s health… And prosecution threatens to prosecute those who spread rumors about “the arrangement of the ruling house”.

United Arab Emirates (CNN) — Kuwaiti Emir Sheikh Nawaf Al-Ahmad Al-Jaber Al-Sabah’s health condition was confirmed on Saturday by the Minister of Emirati Diwan Affairs, Sheikh Muhammad Al-Abdullah Al-Sabah. It is stable, thanks to God Almighty,” Kuwait News Agency reported. “Kona.”

The minister added: “We pray to the Almighty God for a speedy recovery to the Emir of the country and to grant him good health and complete well-being.”

The Minister of Amiri Diwan Affairs said on Wednesday that the health of the Emir of Kuwait is stable and he is still receiving the necessary treatment.

Earlier, the Amiri Diwan minister said the Kuwaiti emir “entered the hospital to receive treatment and undergo a medical examination following a health condition”.

For its part, the Kuwaiti Public Prosecution warned in a statement on Saturday against “taking decisive action and filing criminal charges against every individual, group, platform, media, radio station or any organization that publishes or addresses anything related to the health of the Emir or the arrangement of the ruling house.”

The Kuwait Public Prosecution added: “We have been monitoring many false reports and shocking lies in the media, and by individuals on visual, audio and print media platforms, about the health of the Emir of the country or the arrangements of the ruling house. According to Kuna.

Rumor mongers have used the word as a weapon to spread poison in the society using flimsy pretexts of freedom of expression, good intentions and fear, forgetting the harmful effects of rumours. According to the Kuwaiti Agency, there is more than a raging plague.

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