science
Alzheimer’s: Donanimab may be a breakthrough in treating and slowing the disease
- author, Fergus Walsh and Michael Roberts
- stock, BBC News
A new drug called donanimab has been hailed as a breakthrough in the fight against Alzheimer’s disease, with results from a global trial confirming that it slows cognitive decline.
The antibody drug helps people with this type of dementia in the early stages of the disease by removing the protein that builds up in the brain.
Although there is no cure for everything, the charities say the findings, published in JAMA The Journal of the American Medical Association, mark a new era in the treatment of Alzheimer’s disease.
England’s Medicines Regulatory Authority has begun evaluating it for potential use in the National Health Service (NHS).
The drug works in Alzheimer’s disease but not in other types of dementia, such as vascular dementia.
In trials, it appears to slow the progression of the disease by a third, allowing people to maintain most of their daily living and tasks such as preparing meals and enjoying entertainment.
Mike Cooley, 80, was one of dozens of patients in the UK who took part in the global trial, and his family spoke exclusively to the BBC.
Mike receives injections of the drug every month at a clinic in London and says he is “one of the luckiest people in the world”.
Mike Cooley (left) with his son Mark
Mike and his family noticed that he was having trouble with memory and decision-making shortly before he began participating in the experiment.
His son Mark said watching his father struggle was tough at first: “Watching him struggle with information processing and problem solving was tough, but I think the regression is on the way to stabilization.”
He added, “I feel more confident every day.”
Eli Lilly’s drug tonanimab, which works similarly to leganimab – developed by Ise and Biogen – made headlines around the world when it was shown to slow the progression of the disease.
Although these drugs are very promising, they are not risk-free treatments.
Brain enlargement was a common side effect in one-third of patients in the dunamib trial, and most of them resolved asymptomatically. However, two volunteers and one-third died as a result of severe enlargement. the brain.
Another Alzheimer’s drug, aducanumab, was recently rejected by European regulators because of safety concerns and insufficient evidence of its effectiveness in patients.
What is dementia and what can be done about it?
In the dunanimab trial, researchers studied 1,736 people aged 60 to 85 with early-stage Alzheimer’s disease.
Half of them received a monthly injection of the treatment, while the other half received a placebo, also known as a dummy drink, over an 18-month period.
- The drug appears to have a moral advantage, at least for some patients.
- People with early-stage disease who initially had less amyloid in the brain benefited more, based on clarity seen on brain scans.
- Those who received the drug were able to maintain their daily lives, such as discussing current events, answering the phone, and pursuing hobbies.
- Depending on what people do in their daily lives, the disease declines as the researchers estimate that 20-30% overall and 30-40% of patient groups are more likely to respond.
- Significant side effects have occurred and patients should be made aware of the risks of treatment.
- About half of the patients who received dunanimab were able to stop treatment after one year because it sufficiently cleared brain deposits.
Amyloid is only one part of the complex picture of Alzheimer’s disease, and it’s unclear whether treatment will continue to make a big difference over the long term, experts caution.
The drug’s effects may be modest, but the results further confirm that removing amyloid from the brain can reverse the course of Alzheimer’s disease and help people with this serious disease if treated in time.
Professor Giles Hardingham, from Dementia Research UK, said: “It’s great to see these findings published in full today. We’ve waited a long time for a cure for Alzheimer’s, so it’s really encouraging to see continued solid progress in this area.”
Dr Susan Koolhaas from Alzheimer’s Research UK said: “Today’s announcement marks another milestone. Thanks to decades of research, expectations about dementia and its impact on people and society are finally starting to change, and we are entering a new era of Alzheimer’s disease being treatable.”
Speaking on BBC Radio 4’s BM programme, former Prime Minister David Cameron said evidence should be turned on to further research into what he called “statins for the brain”.
He said: “We want a pill that can be taken daily or weekly by people with excess of these proteins in the brain to clear the proteins in the brain, thereby reducing the chances of developing the disease that causes dementia.”
Asked if the government was prepared to invest where necessary to roll out new treatments, Mr Cameron said there was a real incentive to do so: “We are a country of sixty million people and a million people with dementia, many of whom have very expensive residential care systems, so we cannot treat people effectively. A lot of savings can be made through… I am confident that our system can achieve that.”
Licensed Licanimab costs about $27,500 in the United States.
It is unclear how much tonanimab will cost and how long it might take to gain approval in the UK, but Alzheimer’s experts said having two drugs could help promote price competition.
The UK’s Medicines Regulatory Authority has announced that it has already started work evaluating dunanimab for the treatment of mild cognitive impairment or mild dementia caused by Alzheimer’s disease.
A spokesman for the Medicines Regulatory Commission said: “Our aim is to make recommendations on its use (for the NHS) as soon as possible after receiving the UK licence.”
Mike is celebrating his 80th birthday
Mike Cooley celebrated his 80th birthday in April. At his birthday party, he surprised his family by performing “My Way” in front of 40 guests.
“That’s the confidence I have now, I wouldn’t have done it 12 months ago,” he told the BBC.
His son Mark added: “I never expected to see my dad so lively again, it was an incredible moment.”
Dr Emer McSweeney, a consultant in neurodiagnostic radiology who led the trials of tonanimab in the UK, said: “This is very important and one of the major breakthroughs.”
The Alzheimer’s Association said: “This is truly a breakthrough in the fight against the disease, and science is proving that it is possible to slow the disease.”
Around 720,000 people in the UK could benefit from these new treatments for the disease if they were approved for use, but the Alzheimer’s Association said the NHS was not fully prepared to provide them.
Kate Lee, chief executive of the charity, said: “Correct and prompt diagnosis is vital, as only 2% of people in England and Wales currently receive their diagnosis through the specialist tests needed to qualify for these treatments.”
“Furthermore, these emerging Alzheimer’s drugs require regular injections and follow-up, and the National Health Service’s preparations for implementing them on a large scale are not yet complete.”
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science
Home Covid-19 tests are valid for detecting new strains
Director of the Clinical Virology Laboratory at the American Mayo Clinic, Dr. Matthew Pinker answers frequently asked questions about the expiration dates of home testing kits for “Covid-19” and their ability to detect new strains of the virus.
Home tests
* Validity of test instruments. At-home Covid-19 tests allow you to collect your own sample and detect active Covid-19 infection. But what if you have expired or outdated Covid-19 test kits at home in your cupboard?
Dr. Matthew Pinker says: Companies arbitrarily plan original test kits; Because the development of these at-home diagnostic tests was rapid. Therefore; Check your tools before throwing them away.
“Now three and a half years into the epidemic, these manufacturers have had the opportunity to evaluate the effectiveness of the test over a longer period of time,” Dr. Pinker adds. “In many cases the expiration dates have been updated.”
Recommendations on accuracy of tests
-If you have test kits at home, search the US Food and Drug Administration (FDA) website for updated expiration dates.
– “If you take a test after the expiration date and the test is positive, this is a reliable result, especially if you have a respiratory disease.
If you get a negative result from a test that’s past the expiration date, “I recommend making sure the test doesn’t have an extended expiration date.” Beyond that, you should get another test or ask your healthcare provider to collect a swab for lab testing before ruling you (Covid-19) free,” says Dr. Beneker.
Tracking current “corona” strains
* Can home tests detect current strains of “Covid-19”?
– Yes, it should detect currently circulating covid-19 strains. The good news is that most of the changes to the virus within these new variants are in the spike protein, the part of the virus that attaches to cells.
“The protein that the antigen tests are looking for is a different protein where there aren’t many mutations,” says Dr. Pinker. “This allows us to say with confidence that these tests should pick up cyclic strains.”
Test results
*If the test comes back positive (confirmed), are you contagious? What if you test positive for coronavirus (Covid-19)?
Often, Dr. Benniker says, “when the home antigen test is positive, it means that this person is still secreting large amounts of viral protein.” “In most cases, that means the person is excreting that amount of virus, and it can be a large amount of virus that can spread from one person to another.” If you get a positive result, he adds. Antigen testing at home Consider risk of viral transmission. If the result is positive, you may be infected with Covid-19.
*But what if you develop symptoms and test negative?
“If you test negative at home and are still experiencing common symptoms of Covid-19, such as a sore throat, cough, fever and body aches, I recommend that you visit your healthcare provider and get tested.” Dr. Pinker says. This is because “the collected swab can be sent to the laboratory and tested based on the polymerase chain reaction. This will give us more reliable information about whether you are actually infected with (Covid-19) or not.
When is the test done?
* When should you get tested for “COVID-19”?
Testing is recommended in some situations, Dr. Pinker says. Such as:
. Symptoms appear. If you develop symptoms such as fever, cough, sore throat, runny nose or body aches.
. If you spend time with someone who has been confirmed to have the coronavirus (COVID-19).
. If you plan to visit someone who is at risk of serious illness. This includes someone with cancer, the elderly, or anyone taking medications that suppress their immune system. If you’re infected with the virus, don’t get yourself tested right away, Dr. Pinker says. “My advice is to wait a few days and not go straight home and get tested; This is because the virus does not have enough time to reach levels that would cause antigen tests to be positive. “Usually, I wait three days after that.”
. Exposure, then testing. If the result is negative, consider another test the next day or 48 hours later; Generally, by the fifth day after exposure, if you test negative within that time frame, you can clear the virus.
Atmospheric temperature and accuracy of tests
* Home temperature and “Covid-19” testsSince temperatures fluctuate greatly in geographic regions, would these tests be affected by hot or cold temperatures?
Information packages accompanying at-home antigen tests should provide information on storage conditions set by the Food and Drug Administration, Dr. Pinker says. Here is a good read. “If you live in an area that experiences subzero weather, such as during the summer months, or temperatures above 100 degrees F (37.8 C), it’s always a good idea to check the package that comes with the test for acceptable storage conditions.
* “Mayo Clinic News Network” – “Tribune Media” Services
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science
Why not keep your toothbrush in the bathroom?
RT
We all know that maintaining oral hygiene is very important and the most important step to do this is to brush your teeth twice a day with mouthwash and floss.
But according to experts, you could be putting your oral hygiene at risk by storing your toothbrush in the bathroom.
“Storing your toothbrush in the bathroom can expose you to a variety of health problems, but the level of risk varies depending on the bathroom environment and your specific habits,” explains Dr. Payal Bhalla, principal dentist and medical director of Quest Dental.
Dr. Balla says that aerosolized bacteria can pose a problem because “when you flush the toilet, especially when the lid is open, small droplets containing bacteria and other microorganisms can splash out and settle on nearby surfaces, including your toothbrush.”
When your toothbrush is near the toilet, it’s “more likely to come into contact with airborne particles and water splashes” that “lead to contamination.”
Bathrooms can also be a humid environment, which can encourage the growth of bacteria and mold on your toothbrush.
In shared bathrooms, “there is a greater potential for cross-contamination as multiple people use the space and touch different surfaces.”
As for faecal particles, which can be on your toothbrush, Dr. Bhalla explains: “It’s possible to have faecal particles in the bathroom environment, including surfaces like your toothbrush. This can happen when toilets are cleaned. Not closing the lid, and brushing can release small droplets of faecal bacteria and other microbes into the air. .To reduce the risk of faecal particles coming into contact with your toothbrush, you can follow hygiene tips such as rinsing your toothbrush before using it, storing it upright, covering it with the toothbrush, and closing the toilet lid when washing.
She also recommends “rinsing your toothbrush thoroughly under tap water before using it” because it “will help remove any potential contaminants. Also place your toothbrush upright in a toothbrush cup and allow it to air dry. Make sure it doesn’t touch other toothbrushes. ” To prevent cross contamination.
Dr. Bhalla emphasized the importance of changing toothbrushes “every three to four months or so” to keep them healthy and effective.
He added: “To reduce the spread of airborne particles, close the toilet lid before cleaning, use a breathable toothbrush cover to protect your toothbrush from bathroom contaminants, and regularly clean the toothbrush holder or cup to prevent bacteria and mold build-up. “
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science
The Day of the Big Clash… NASA on Historic Mission to Save Earth (Photos)
02:35 PM
Wednesday, September 20, 2023
Scientists believe that September 24, 2182 marks the date that the asteroid “Bennu” will hit the Earth, so the American space agency NASA is preparing to undertake a dangerous mission to prevent a collision and save our planet from destruction.
According to NASA, this space rock passes close to our planet every 6 years, but it will have a very close encounter with Earth after another 159 years, and if it collides with us, its force will be equal to 22 nuclear bombs.
Although the odds of a cataclysmic impact are estimated at 1 in 2,700, NASA sent a spacecraft to Bennu 7 years ago to collect samples from it. They hope the data will help them prepare for an asteroid deflection mission similar to NASA’s DART mission, which successfully changed the orbit of the small asteroid moon Temorphos last year.
The asteroid samples will reach Earth this week, landing in the Utah desert on September 24.
“We’re now in the final stages of this seven-year mission,” Rich Burns, OSIRIS-REx program manager at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, told the Sunday Telegraph.
Bennu is about 492 meters wide (about half the size of the asteroid that killed the dinosaurs), so it wasn’t big enough to cause global extinction.
NASA estimated that it could have an impact 9 kilometers wide and cause devastation in a radius of about 1,000 kilometers from the crash site.
Between now and 2300 the chance of Bennu colliding with Earth is 1750.
“The raw materials from asteroid Bennu will help shed light on how our solar system formed 4.5 billion years ago and how life began on Earth,” said Nicola Fox, associate administrator of NASA’s Science Operations Directorate in Washington.
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