Using a miniature ventricle model, not only cell function but also tissue function and organ function can be studied without the need for certain surgical procedures or animal experiments.
Although research into the treatment of cardiovascular disease has come a long way in recent decades, heart problems kill nearly 18 million people worldwide each year.
But New research Published on July 7 in the journal “Advanced Biology”, it confirmed that there is a glimmer of hope, as Canadian researchers from the universities of “Toronto” and “Montreal” were able to do. (Montreal) created a miniature model of a human left heart ventricle that contains living heart cells and beats hard enough to pump fluid.
The model is expected to open new avenues for the development of new drugs and therapies, and to help study the development of cardiovascular disease, providing researchers with an ethically appropriate and more accurate alternative to currently used methods.
A new way to study heart disease
According to a report published on the “Science Alert” website (Scientific alert); There are usually few options for studying the way a healthy or diseased heart pumps blood.
Fully nonfunctional organs, such as those removed post-mortem, provide cells, and although tissue cultures provide a window into the biochemical functions of these cells, they do not capture the hydraulics of the full 3D, living pulsating mass. .
It’s easy to grow human cells in two dimensions — for example, in a flat Petri dish — and the results don’t look like actual tissues or organs that appear in humans.
That’s why researchers designed a millimeter vessel that beats like real heart cells, but also pumps fluids like a muscle chamber that contracts with great force in a human fetal heart by reverse engineering it.
The study involved three researchers from the Canadian Center for Research and Applications of Fluid Technologies (CRAFT), home to world-leading experts who design, build and test miniature devices to control the flow of fluids at the micron scale. An area called microfluidics.
The team was led by University of Toronto professor Milica Radicek in a unique partnership with Canada’s National Research Council.Press release To the University of Toronto, “The unique facilities at the center enable us to develop such sophisticated organ-on-a-chip models.”
A realistic 3D model of the ventricle
In the human heart, the left ventricle pumps newly oxygenated blood into the aorta and from there to the rest of the body. In this study, cells were obtained from the cardiac tissue of young mice and then cultured on a polymer-printed scaffold layer with well-positioned grooves to guide tissue growth.
This new heart-like organ was grown in a lab using a combination of synthetic and biological materials. This flat network forced the structure to mimic the cardiac muscle fibers of the human left ventricle, the massive final chamber that ejects blood into the aorta with a powerful push.
To make these three-layered heart cells resemble a beating chamber like a simple ventricle, the team used tiny scaffolds made of biocompatible polymers. Scaffolds often decorated with grooves or mesh-like structures are implanted with cardiac muscle cells and allowed to grow in a liquid medium.
Over time, cells grow together to form tissues. The basic shape or form of the scaffold encourages growing cells to align or extend in a particular direction. Continuous electrical stimulation can be used to control the heart rate. “Until now, there have been only a few attempts to create a true 3D model of the ventricle,” says Radicek.
“All of these organs are made up of one layer of cells,” explains Radicek, “but the real heart has multiple layers, and the cells in each layer are oriented at different angles. And when the heart beats, it’s not just these layers. It contracts, they twist, and that’s how it squeezes out water.” It’s like rolling up a towel. It helps the heart pump more blood than otherwise.”
Excellent proof of concept
This vessel, with an internal diameter of half a millimeter, cannot expel fluid at a pressure of 5% of an adult’s heart. However, this model is an excellent proof of concept and can be collected in time to add more tissue layers to represent a more robust system. Over time the scaffold can be removed and a combination of human-derived tissue incorporated, leading to a truly implantable, fully functional organ.
“Using these models (the new ventricular models), we can study not only cell function, but also tissue function and organ function, without the need for certain surgeries or animal experiments,” says Radicek. “These models can be used to screen candidate drug molecules for positive or negative effects,” he says.
The new model could give researchers a new way to study a wide range of heart diseases and conditions, as well as test potential treatments, and allow researchers to test how the living heart acts as a pump under the influence of newly developed treatments.
United Arab Emirates (CNN) — Kuwaiti Emir Sheikh Nawaf Al-Ahmad Al-Jaber Al-Sabah’s health condition was confirmed on Saturday by the Minister of Emirati Diwan Affairs, Sheikh Muhammad Al-Abdullah Al-Sabah. It is stable, thanks to God Almighty,” Kuwait News Agency reported. “Kona.”
The minister added: “We pray to the Almighty God for a speedy recovery to the Emir of the country and to grant him good health and complete well-being.”
The Minister of Amiri Diwan Affairs said on Wednesday that the health of the Emir of Kuwait is stable and he is still receiving the necessary treatment.
Earlier, the Amiri Diwan minister said the Kuwaiti emir “entered the hospital to receive treatment and undergo a medical examination following a health condition”.
For its part, the Kuwaiti Public Prosecution warned in a statement on Saturday against “taking decisive action and filing criminal charges against every individual, group, platform, media, radio station or any organization that publishes or addresses anything related to the health of the Emir or the arrangement of the ruling house.”
The Kuwait Public Prosecution added: “We have been monitoring many false reports and shocking lies in the media, and by individuals on visual, audio and print media platforms, about the health of the Emir of the country or the arrangements of the ruling house. According to Kuna.
Rumor mongers have used the word as a weapon to spread poison in the society using flimsy pretexts of freedom of expression, good intentions and fear, forgetting the harmful effects of rumours. According to the Kuwaiti Agency, there is more than a raging plague.
However, Pfizer announced its intention to develop a modified version of the drug “Danoglipron”.
This drug belongs to a new class of successful treatments based on a component such as the gastrointestinal hormone glucagon or GLP-1 (GLP-1).GLP-1This leads to a feeling of fullness and weight loss.
“Danoglibron” differs from competing drugs already on the market in that it is not given by injection, but is given orally in the form of tablets.
During the clinical trial, Pfizer tested taking these pills twice a day, but said it wanted to focus on a new once-a-day formulation.
The clinical trial included a few hundred obese participants without type 2 diabetes.
Pfizer explained that the side effects in this trial were similar to those that can occur with this type of drug, but “it is noteworthy that their rates were high” because “cases of nausea reached 73 percent, vomiting reached 47 percent, and diarrhea reached 25 percent.”
More than half of the participants who received this drug discontinued treatment.
However, “Danoglipro” has been shown to lead to weight loss between 8 percent and 13 percent over 32 weeks or between 5 percent and 9.5 percent over 26 weeks.
A report quoted Pfizer senior executive Michael Tolston as confirming that “an improved once-daily formulation of tanoglipron could play an important role in the treatment of obesity.”
The highly lucrative anti-obesity drug market is currently dominated by the Danish “Novo Nordisk” group with its drug “Vecovi” and the American “Eli Lilly” company “Zebound”. America last month.
With winter approaching and the seasons fluctuating, many are depressed, especially by things including rain and lack of sunrise, the website says “Health scenesWe show how diet can improve mental health and which foods can help manage it Depression By improving a person’s mood.
The connection between food and your mood
If you eat healthy, you will be healthy; Otherwise, you will have health problems, and when it comes to mental health, nutrition plays an important role.
Foods that help fight depression
Add these foods to your diet to fight depression:
Walnuts are one of the most important nuts for brain health because they help improve cognitive health. Their high levels of antioxidants and vitamins improve mental alertness and fight depression..
Avocados contain healthy fats that help improve cognitive function, memory, and concentration. Apart from that, avocados also contain tryptophan, which helps increase levels of serotonin, which is associated with the hormone of happiness.
The high levels of antioxidants in berries help protect the brain from stress, anxiety and depression, and have been shown to improve mood and cognition..
Broccoli helps keep the memory sharp due to its high amount of choline, and helps reduce depression and support a good mood. .
Eggs are rich in choline, which is one of the most important neurotransmitters in managing stress and depression..