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Japanese scientists are using dried cells to clone mice, aiming to prevent the extinction of the animals

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Japanese scientists are using dried cells to clone mice, aiming to prevent the extinction of the animals

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Japanese scientists have cloned mice using freeze-dried cells, which is still in its infancy, comparable to the research work that resulted in the cloning of the famous “Dolly” sheep. It warned that the extinction of animals in the world is increasing rapidly and that at least one million species will disappear due to the effects of human activities such as climate change.

Japanese scientists have created cloned mice using freeze-dried cells, a technique they hope will one day help preserve the species and overcome current challenges in using biobanking methods.

The United Nations had issued a warning Destruction of animals The world is witnessing an acceleration, and at least one million species may disappear due to the effects of human activities such as climate change. To counter this risk, special facilities for preserving specimens of endangered species have sprung up around the world, with the aim of preventing extinction through future cloning.

These samples are typically preserved by cooling with liquid nitrogen, or at very low temperatures, both of which are expensive and prone to power outages. The samples usually include sperm or egg cells, which are difficult or impossible to obtain from old or sterile animals.

A team of scientists from Japan’s Yamanashi University wanted to see if they could overcome these problems by freeze-drying somatic cells, i.e. cells without sperm or eggs, in an attempt to create clones.

Mating and giving birth to cloned mice

The scientists conducted their experiments on cells from two types of mice and found that even though freeze-drying killed them and caused significant damage to their DNA, they were still able to form clonal blastocysts. From these bags, the scientists extracted the stem cell lines used to produce 75 cloned mice.

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One of the mice lived a year and nine months, while the scientists successfully married female and male clones from two naturally born mice to produce normal mouse pups. The cloned mice produced fewer offspring than would be expected from naturally born mice, while one of the stem cell lines created from male cells was only produced in cloned female mice.

Teruhiko Wakayama, a professor at Yamanashi University’s College of Life and Environmental Sciences, who helped prepare the study published in the journal, said:Natural communication“In the past month, growth should not be difficult. We believe that by searching for agents that protect against freezing and drying and improving drying methods, we can reduce defects and increase the birth rate in the future.”

For example, cloning mice from cells stored in liquid nitrogen or at very low temperatures has a success rate of 2 to 5 percent, while the freeze-drying technique has a success rate of only 0.02 percent.

Compared to the research work that resulted in the successful cloning of “Dolly” the sheep after more than two hundred attempts, Wakayama found the technique still in its infancy. “The most important thing is that the cloned mice were created from freeze-dried somatic cells, and we have made significant progress in this area,” he said.

Conservation of genetic resources

While the technology is unlikely to completely replace cryopreservation, “this is an important advance for scientists interested in global biodiversity threatened by biobanking methods,” says Simon Clolo, senior research fellow at the University of Canberra’s Center for Environmental and Genetic Conservation. “Cryopreservation protocols can be difficult and expensive to work with, so alternatives, especially those that are less expensive and more efficient, are very welcome,” said Clolo, who was not involved in the study.

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The scientists in the study stored the freeze-dried cells at minus 30 degrees Celsius, but they had previously found that freeze-dried mice sperm could survive at room temperature for at least a year, and they believed somatic cells would remain. React in the same way. Wakayama explained that the technology “may eventually allow us to save the entire world’s genetic resources at a lower cost and more safely.”

This research work is an extension of several years of research on cloning and freeze-drying techniques carried out by Wakayama and colleagues. One of their recent researches involved freeze-dried mouse sperm and sent to the International Space Station. Despite six years in space, the cells were successfully rehydrated after returning to Earth, producing healthy young mice.

France 24/AFP

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Mohamed bin Said discusses “COP28” issues with the President of Poland and the Prime Ministers of Italy and Albania

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Mohamed bin Said discusses “COP28” issues with the President of Poland and the Prime Ministers of Italy and Albania

The Head of State, Sheikh Mohammed bin Zayed Al Nahyan, may God protect him, met yesterday with the heads of several delegations participating in the Conference of the Parties to the United Nations Framework Convention on Climate Change (COP28). Held at Expo City in Dubai.

This came within the framework of His Highness’ intensive meetings with leaders and officials on the sidelines of the conference.

During his meeting – separately – the President of the Republic of Poland, Andrzej Duda, the Prime Minister of the Italian Republic, Giorgia Meloni, in addition to the Prime Minister of the Republic of Albania, Edi Rama, discussed their high-level bilateral relations. UAE and its allies, and ways to push them forward in various fields, especially development sectors, in addition to some regional and international issues of common interest.

The Head of State also reviewed with the guests the issues raised at (COP28) and the importance of joint work through the conference to produce practical and impactful results. Dangerous consequences of climate change around the world.

During these meetings, leaders and heads of delegations praised the efforts of Sheikh Mohammed bin Zayed Al Nahyan in his speech at the World Climate Action Summit, announcing the importance of establishing a $30 billion fund for global climate solutions. This initiative is reflected in bridging the funding gap, in the field of global climate action.

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A 4,000-tonne Emirati aid ship departed from Fujairah in support of the Palestinian brothers.

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A 4,000-tonne Emirati aid ship departed from Fujairah in support of the Palestinian brothers.

An Emirati aid ship loaded with 4,016 tons of humanitarian supplies left this afternoon for Al-Arish in preparation for their entry into the Gaza Strip, as part of the humanitarian operation “Qaland Night 3” implemented by His Highness. Sheikh Mohammed bin Zayed Al Nahyan, head of state, “may God protect him”, to support the people, brother Palestinians in the Gaza Strip..

The ship, which departed from Fujairah port, carried 3,465 tonnes of food, 420 tonnes of shelter and 131 tonnes of medical aid, both donated by the Khalifa bin Zayed Al Nahyan Foundation and the Foundation for Humanitarian Affairs. The Zayed Bin Sultan Al Nahyan Foundation, in addition to the Emirates Red Crescent Authority, for charitable and humanitarian work..

The Head of State, Sheikh Mohammed bin Zayed Al Nahyan, may God protect him, last November 5 ordered the Joint Operations Command of the Ministry of Defense to launch “The Gallant Night 3”, a humanitarian operation to support the Brotherhood. Humanitarian support to the Palestinian people, in cooperation with humanitarian agencies in the country..

The UAE’s total aid to the fraternal Palestinian people before December 1 was more than 2,681 tons, while the total number of aircraft in the UAE airlift reached 92 aircraft..

The UAE’s commitment embodies the values ​​of solidarity and synergy with the brotherly Palestinian people, based on a long history of relief and humanitarian work during which the UAE is keen to provide all possible support..

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As aggression on Gaza resumes… Withdrawal, withdrawal, condemnations from climate conference in Dubai

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As aggression on Gaza resumes… Withdrawal, withdrawal, condemnations from climate conference in Dubai

A devastating Israeli resumption of war in Gaza on Friday overshadowed the United Nations Climate Change Conference (COP28) in Dubai, with some delegates walking out, leaders canceling their speeches and others not attending the event.

In his speech, Turkish President Recep Tayyip Erdogan said, “As a result of Israel’s occupation, we cannot avoid facing the humanitarian crisis in our neighboring Palestinian territories, which cannot be justified under any circumstances.” He considered it a “crime against humanity and a war crime”.

In turn, the presidents of Colombia and Cuba described the war as “genocide”.

The Emir of Qatar, Sheikh Tamim bin Hamad Al Thani, was not included in the final list of speakers after his name appeared.

Saudi Crown Prince Mohammed bin Salman was scheduled to be the first speaker, but did not attend the summit.

“As we see in the region, conflicts are causing great suffering and emotion,” UN Secretary-General Antonio Guterres said at the summit. “We heard reports of renewed bombs in Gaza.”

Iranian delegates walked out of the conference in protest at the sudden Israeli presence, which the head of the delegation, Energy Minister Ali Akbar Mehrabian, described as “contrary to the goals and directions of the conference.”

Iranian official media reported on Thursday that President Ibrahim Raisi would not attend the conference and that Mehrabian would act in his stead.

Iraqi President Abdul Latif Rashid used his speech to condemn the aggression against Gaza, calling on the international community to “stand firm”.

A war against innocent people

South African President Cyril Ramaphosa said his country was “appalled by the ongoing tragedy in Gaza, and that the war against innocent people in Palestine is a war crime that must stop.”

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Other leaders have also criticized the war in Gaza, but Egyptian President Abdel Fattah al-Sisi has not spoken about it.

Israeli President Isaac Herzog canceled his speech, a day after Palestinian President Mahmoud Abbas canceled his participation in the conference, as the war in Gaza dominated the conference’s deliberations.

So far, the Israeli occupation of Gaza has led to the fall of more than 15,000 martyrs, most of them women and children.

Israel says 1,200 Israeli soldiers and settlers have been killed as a result of Operation Al-Aqsa flooding, which was launched by the opposition on October 7 last year in settlements around Gaza.

The Palestinian opposition said the move came in retaliation for crimes of aggression against civilians in the West Bank and Gaza and the desecration of the blessed Al-Aqsa Mosque.

It is noteworthy that the United Arab Emirates, the host country of the conference, is one of the Arab countries that signed default agreements with Israel in 2020.

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